On Wednesday 14 June shortly before 11.20pm police received reports of a drone hovering over HMP Risley.
Local officers swiftly attended the scene and conducted a thorough search of the area.
Two men aged 17 and 18 were arrested at the scene, and a further two men aged 31 and 41 were arrested a short time later near to the M62, Birchwood.
All four men are being held on suspicion of being concerned in the supply of Class A drugs - they are currently assisting officers with their enquiries.
The men are believed to have been using a drone to smuggle Class A drugs into the prison. The drone and a quantity of drugs were recovered at the scene.
Chief Inspector Sarah Pengelly from Warrington Local Policing Unit said: “I hope that these arrests send a clear message that the supply of drugs has consequences.
“We are committed to tackling drug crime and I urge anyone with any information about suspected drug related activity in their local communities to get in touch.”
Anyone with any information about drugs or crime in their local community is asked to contact Cheshire police on 101. Alternatively information can also be reported anonymously to Crimestoppers on 0800 555 111.