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Police are appealing for witnesses following a collision on the A49 near to Acton Bridge.
The collision occurred at around 11.15pm on Thursday 24 June involving two vehicles – a silver Seat Leon and a black Mercedes CLK.
Two males and two females inside the Seat Leon were taken to hospital by ambulance with injuries believed to be serious but not life threatening.
A 32-year-old man driving the Mercedes was taken to Warrington Hospital by ambulance and his injuries are believed to be minor.
The road was closed for several hours while investigators remained at the scene and has since reopened.
Police are keen to hear from anyone who witnessed the collision take place and appealing for dashcam footage that could assist with enquiries.
Sergeant Andrew Dennison, from the Serious and Complex Investigation Unit, said: “Our enquiries remain ongoing to establish the circumstances surrounding the collision that took place.
“As part of our investigation we would like to hear from members of the public who may have seen the collision, or have any information, to get in touch.
“I am also keen for people to submit any dashcam footage they have that could assist with the investigation.”
If you have information or dashcam footage please contact Cheshire Constabulary on 101 quoting IML 1021591 or visit the website https://www.cheshire.police.uk/